..., a reliable method for the quantification of the anisotropic mechanical properties of human white matter is currently lacking, despite the potential to illuminate the pathophysiology behind neurological disorders and traumatic brain injury. In this study, we examine the use of multiple excitations in MRE...

... studies have investigated the biochemical and genetic aspects of ASD, whether and how mechanical characteristics of the autistic brain can modulate neuronal connectivity and cognition in ASD are unknown. Previously, it has been shown that ASD brains are characterized by abnormal white matter...

...Yun-Seok Kang; Kevin Moorhouse; John H. Bolte, IV The ability to measure six degrees of freedom (6 DOF) head kinematics in motor vehicle crash conditions is important for assessing head-neck loads as well as brain injuries. A method for obtaining accurate 6 DOF head kinematics in short duration...

...Benjamin S. Elkin; Ashok Ilankova; Barclay Morrison, III Stress relaxation tests using a custom designed microindentation device were performed on ten anatomic regions of fresh porcine brain (postmortem time <3 h). Using linear viscoelastic theory, a Prony series representation was used...

... 2010 10 03 2011 28 03 2011 03 05 2011 03 05 2011 biological tissues biomechanics brain elasticity finite element analysis inverse problems cerebral aneurysms tissue property pointwise identification method in vivo identification Cerebral aneurysms (CAs...

... of deformation. We demonstrate the use of this methodology by determining the minimal rheological arrangement, constitutive relationships, and model parameters for the structural response of various soft tissues, including ex vivo perfused porcine liver in indentation, ex vivo porcine brain cortical tissue...

...Guanglei Li; Bingmei M. Fu The endothelial surface glycocalyx layer (SGL) and the basement membrane (BM) are two important components of the blood-brain barrier (BBB). They provide large resistance to solute transport across the BBB in addition to the tight junctions in the cleft between adjacent...

...Andrew K. Knutsen; Yulin V. Chang; Cindy M. Grimm; Ly Phan; Larry A. Taber; Philip V. Bayly Folding of the cerebral cortex is a critical phase of brain development in higher mammals but the biomechanics of folding remain incompletely understood. During folding, the growth of the cortical surface...

... to both proximal and distal sides of the sac. 01 06 2009 16 02 2010 22 02 2010 26 08 2010 26 08 2010 blood vessels brain computational fluid dynamics diseases haemodynamics medical computing neurophysiology physiological models aneurysms animal models...

...Gang Xu; Andrew K. Knutsen; Krikor Dikranian; Christopher D. Kroenke; Philip V. Bayly; Larry A. Taber During human brain development, the cerebral cortex undergoes substantial folding, leading to its characteristic highly convoluted form. Folding is necessary to accommodate the expansion...

...O. Ivanchenko; N. Sindhwani; A. Linninger Convection enhanced delivery is an attractive option for the treatment of several neurodegenerative diseases such as Parkinson, Alzheimer, and brain tumors. However, the occurrence of a backflow is a major problem impeding the widespread use...

...Benjamin S. Elkin; Ashok Ilankovan; Barclay Morrison, III Age-dependent outcomes following traumatic brain injury motivate the study of brain injury biomechanics in experimental animal models at different stages of development. Finite element models of the rat brain are used to better understand...

...Gang Xu; Philip S. Kemp; Joyce A. Hwu; Adam M. Beagley; Philip V. Bayly; Larry A. Taber Mechanical forces play an important role during brain development. In the early embryo, the anterior end of the neural tube enlarges and differentiates into the major brain subdivisions, including three...

... ( 15 16 ) but long term freezing damages nervous tissue and has been purposefully avoided ( 6 14 ). In contrast, partial freezing of brain tissue before cutting did not affect the mean mechanical response but added one hour to the specimen preparation process ( 7 ). Preloading is another method...

... accumulation patterns. Figures 7 8 , respectively, presented the elastic strain energy density and damage distributions of four types of models of six selected specimens at their respective compressive maximum force. 03 09 2008 20 05 2009 16 10 2009 biomechanics bone brain finite...

.... B. , 1995 , “ Three-Dimensional Collagen Organization of Human Brain Arteries at Different Transmural Pressures ,” J. Vasc. Res. 1018-1172 , 32 ( 5 ), pp...

... , J. G. , 1991 , “ Medial Collagen Organization in Human Arteries of the Heart and Brain by Polarized Light Microscopy ,” Connect. Tissue Res. 0300-8207 , 26 , pp. 121 – 134 . 10.3109/03008209109152168 Rowe , A. J. , Finlay , H. M. , and Canham , P. B. , 2003...

.... , and Sinha , S. , 2007 , “ Fluid-Induced WSS in Anthropomorphic Brain Aneurysm Models: MR Phase-Contrast Study at 3T ,” J. Magn. Reson Imaging 1053-1807 , 25 , pp. 1120 – 1130 . 10.1002/jmri.20928 Hoi , Y. , Meng , H. , Woodward , S. H. , Bendok , B. R. , Hamel , R...

... on flow and fluid mechanical forces within the aneurysm. The choice of constitutive model has measurable influence on the numerical prediction of aneurysm rupture risk due to fluid stresses, though less influence than aneurysm morphology. biomechanics blood vessels brain diseases haemodynamics...

...Kazuto Masamoto; Kazuo Tanishita Oxygen is essential to maintaining normal brain function. A large body of evidence suggests that the partial pressure of oxygen ( p O 2 ) in brain tissue is physiologically maintained within a narrow range in accordance with region-specific brain activity. Since...