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Keywords: drug delivery systems
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Journal Articles

Designing and Testing of Backflow-Free Catheters

O. Ivanchenko, V. Ivanchenko
Journal: Journal of Biomechanical Engineering
Article Type: Research Papers
J Biomech Eng. June 2011, 133(6): 061003.
https://doi.org/10.1115/1.4004286
Published Online: June 20, 2011
... . 10.3171/jns.2004.101.2.0314 20 Hall , C. W. , 2000 , Laws and Models: Science, Engineering, and Technology , CRC , Boca Raton, FL . biological fluid dynamics catheters convection diseases drug delivery systems microfluidics neurophysiology Neurodegenerative diseases...
View Article titled, Designing and Testing of Backflow-Free Catheters
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Topics: Catheters, Design
Journal Articles

Ballistic Impact of Single Particles Into Gelatin: Experiments and Modeling With Application to Transdermal Pharmaceutical Delivery

R. A. Guha, N. H. Shear, M. Papini
Journal: Journal of Biomechanical Engineering
Article Type: Research Papers
J Biomech Eng. October 2010, 132(10): 101003.
https://doi.org/10.1115/1.4002428
Published Online: September 28, 2010
.... 0022-202X , 93 ( 3 ), pp. 353 – 357 . 10.1111/1523-1747.ep12280259 31 03 2010 05 08 2010 24 08 2010 28 09 2010 28 09 2010 biomechanics biomedical materials drug delivery systems elastic moduli finite element analysis gelatin gold powders skin drug...
View Article titled, Ballistic Impact of Single Particles Into Gelatin: Experiments and Modeling With Application to Transdermal Pharmaceutical Delivery
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Topics: Gelatin, Particulate matter, Skin, Steel, Finite element model
Journal Articles

Effects of Virus Size and Cell Stiffness on Forces, Work, and Pressures Driving Membrane Invagination in a Receptor-Mediated Endocytosis

Amit Gefen
Journal: Journal of Biomechanical Engineering
Article Type: Technical Briefs
J Biomech Eng. August 2010, 132(8): 084501.
https://doi.org/10.1115/1.4001888
Published Online: June 28, 2010
... 2010 27 05 2010 28 06 2010 28 06 2010 biomechanics biomembranes cellular biophysics drug delivery systems elastic moduli indentation microorganisms nanobiotechnology biomechanical cell model cellular mechanics virus engulfment The process by which viruses...
View Article titled, Effects of Virus Size and Cell Stiffness on Forces, Work, and Pressures Driving Membrane Invagination in a Receptor-Mediated Endocytosis
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Topics: Biomechanics, Cellular mechanics, Elastic moduli, Membranes, Stiffness, Contact mechanics
Journal Articles

Experimental Techniques for Studying Poroelasticity in Brain Phantom Gels Under High Flow Microinfusion

O. Ivanchenko, N. Sindhwani, A. Linninger
Journal: Journal of Biomechanical Engineering
Article Type: Research Papers
J Biomech Eng. May 2010, 132(5): 051008.
https://doi.org/10.1115/1.4001164
Published Online: March 29, 2010
... in Agarose Gels and Intervertebral Disc: Effect of Porosity ,” Ann. Biomed. Eng. 0090-6964 , 32 ( 12 ), pp. 1710 – 1717 . 10.1007/s10439-004-7823-4 18 11 2009 27 01 2010 02 02 2010 29 03 2010 biological fluid dynamics brain catheters deformation drug delivery...
View Article titled, Experimental Techniques for Studying Poroelasticity in Brain Phantom Gels Under High Flow Microinfusion
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Topics: Biological tissues, Brain, Catheters, Deformation, Displacement, Flow (Dynamics), Fluids, Hydraulic conductivity, Polariscopes, Porosity
Journal Articles

Peptide- and Aptamer-Functionalized Nanovectors for Targeted Delivery of Therapeutics

Todd O. Pangburn, Matthew A. Petersen, Brett Waybrant, Maroof M. Adil, Efrosini Kokkoli
Journal: Journal of Biomechanical Engineering
Article Type: Technology Review
J Biomech Eng. July 2009, 131(7): 074005.
https://doi.org/10.1115/1.3160763
Published Online: July 31, 2009
... Targeted to Activated Platelets as a Potential Vascular Drug Delivery System ,” Thromb. Haemostasis 0340-6245 , 93 ( 1 ), pp. 106 – 114 . Lee , G. , Chan , W. , Hurle , M. R. , Desjarlais , R. L. , Watson , F. , Sathe , G. M. , and Wetzel , R. , 1993 , “ Strong...
View Article titled, Peptide- and Aptamer-Functionalized Nanovectors for Targeted Delivery of Therapeutics
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Topics: Cancer, DNA, Drug delivery systems, Drugs, Nanoparticles, Proteins, Tumors, Vehicles, Patient treatment
Journal Articles

Voxelized Model of Interstitial Transport in the Rat Spinal Cord Following Direct Infusion Into White Matter

Jung Hwan Kim, Garrett W. Astary, Xiaoming Chen, Thomas H. Mareci, Malisa Sarntinoranont
Journal: Journal of Biomechanical Engineering
Article Type: Research Papers
J Biomech Eng. July 2009, 131(7): 071007.
https://doi.org/10.1115/1.3169248
Published Online: July 16, 2009
... distributions following CED into the spinal cord. Quantification of these transport fields provides an important step toward development of drug-specific transport models of infusion. 06 11 2008 26 05 2009 16 07 2009 biological tissues biomedical MRI biotransport brain drug delivery...
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Topics: Biological tissues, Imaging, Spinal cord, Tensors, Diffusion (Physics), Resolution (Optics), Image segmentation
Journal Articles

Freezing-Assisted Intracellular Drug Delivery to Multidrug Resistant Cancer Cells

Ka Yaw Teo, Bumsoo Han
Journal: Journal of Biomechanical Engineering
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074513.
https://doi.org/10.1115/1.3153325
Published Online: June 29, 2009
... cellular biophysics drug delivery systems freezing melting molecular biophysics permeability proteins multidrug resistance drug delivery freezing quantitative fluorescence microscopy Multidrug resistance (MDR) of cancer cells impairs the efficacy of chemotherapy by decreasing...
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Topics: Cancer, Drug delivery systems, Drugs, Freezing, Proteins, Fluorescence, Membranes, Cell membranes, Microscopy
Journal Articles

Three-Dimensional Computational Modeling of Subject-Specific Cerebrospinal Fluid Flow in the Subarachnoid Space

Sumeet Gupta, Michaela Soellinger, Peter Boesiger, Dimos Poulikakos, Vartan Kurtcuoglu
Journal: Journal of Biomechanical Engineering
Article Type: Research Papers
J Biomech Eng. February 2009, 131(2): 021010.
https://doi.org/10.1115/1.3005171
Published Online: December 10, 2008
... biological fluid dynamics biomedical MRI brain computational fluid dynamics drug delivery systems finite volume methods optimisation porous materials pulsatile flow cerebrospinal fluid subarachnoid space porous media MRI drug delivery The cerebrospinal fluid (CSF) is a colorless...
View Article titled, Three-Dimensional Computational Modeling of Subject-Specific Cerebrospinal Fluid Flow in the Subarachnoid Space
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Topics: Cerebrospinal fluid, Computational fluid dynamics, Flow (Dynamics), Magnetic resonance imaging, Porous materials, Pressure, Brain, Drug delivery systems, Permeability, Cardiac cycle
Journal Articles

Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations

Sandra Rugonyi
Journal: Journal of Biomechanical Engineering
Article Type: Research Papers
J Biomech Eng. April 2008, 130(2): 021010.
https://doi.org/10.1115/1.2899571
Published Online: March 28, 2008
... layer concentrations under physiological conditions. biochemistry biodiffusion biomedical measurement blood blood vessels boundary layers cardiovascular system cellular biophysics drug delivery systems drugs finite element analysis fluid oscillations haemodynamics mass transfer...
View Article titled, Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations
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Topics: Boundary layers, Drugs, Blood, Blood flow, Finite element model, Diffusion (Physics), Flow (Dynamics), Drug delivery systems, Blood vessels
Journal Articles

Effects of Diffusion Coefficients and Struts Apposition Using Numerical Simulations for Drug Eluting Coronary Stents

Rosaire Mongrain, Isam Faik, Richard L. Leask, Josep Rodés-Cabau, Éric Larose, Olivier F. Bertrand
Journal: Journal of Biomechanical Engineering
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 733–742.
https://doi.org/10.1115/1.2768381
Published Online: February 22, 2007
... biodiffusion blood vessels drug delivery systems haemodynamics physiological models polymer films drug eluting stents drug delivery diffusion therapeutic window restenosis Drug eluting stents (DESs) are coated with drugs that inhibit smooth muscle cells and myofibroblasts replication...
View Article titled, Effects of Diffusion Coefficients and Struts Apposition Using Numerical Simulations for Drug Eluting Coronary Stents
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Topics: Blood, Coatings, Diffusion (Physics), Drugs, Polymers, Stents, Struts (Engineering), Computer simulation
Journal Articles

Targeted Drug Aeroso Deposition Analysis for a Four-Generation Lung Airway Model With Hemispherical Tumors

C. Kleinstreuer, Z. Zhang
Journal: Journal of Biomechanical Engineering
Article Type: Technical Papers
J Biomech Eng. April 2003, 125(2): 197–206.
https://doi.org/10.1115/1.1543548
Published Online: April 9, 2003
...C. Kleinstreuer; Z. Zhang One important research area of broad interest is the development of highly efficient drug delivery systems for desired site deposition and uptake. For example, controlled drug aerosol release and targeting to specific regions of the lung is a novel way to combat lung...
View Article titled, Targeted Drug Aeroso Deposition Analysis for a Four-Generation Lung Airway Model With Hemispherical Tumors
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Topics: Lung, Particulate matter, Tumors, Drugs, Aerosols, Bifurcation, Flow (Dynamics)
Journal Articles

Inertial Deposition Effects: A Study of Aerosol Mechanics in the Trachea Using Laser Doppler Velocimetry and Fluorescent Dye

T. E. Corcoran, Norman Chigier
Journal: Journal of Biomechanical Engineering
Article Type: Technical Papers
J Biomech Eng. December 2002, 124(6): 629–637.
https://doi.org/10.1115/1.1516572
Published Online: December 27, 2002
... intersubject variability based on different breathing parameters, anatomical differences etc. aerosols drug delivery systems turbulence light interferometry laser velocimetry Doppler measurement lung biological organs pneumodynamics laser applications in medicine fluorescence 01...
View Article titled, Inertial Deposition Effects: A Study of Aerosol Mechanics in the Trachea Using Laser Doppler Velocimetry and Fluorescent Dye
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Topics: Aerosols, Flow (Dynamics), Trachea, Turbulence, Lung, Laser Doppler anemometry