Current theories of stroke rehabilitation point toward paradigms of intense concentrated use of the afflicted limb as a means for motor program reorganization and partial function restoration. A home-based system for stroke rehabilitation that trains recovery of hand function by a treatment of concentrated movement was developed and tested. A wearable goniometer measured finger and wrist motions in both hands. An interface box transmitted sensor measurements in real-time to a laptop computer. Stroke patients used joint motion to control the screen cursor in a one-dimensional tracking task for several hours a day over the course of 10–14 days to complete a treatment of 1800 tracking trials. A telemonitoring component enabled a therapist to check in with the patient by video phone to monitor progress, to motivate the patient, and to upload tracking data to a central file server. The system was designed for use at home by patients with no computer skills. The system was placed in the homes of 20 subjects with chronic stroke and impaired finger motion, ranging from 2–305 mi away from the clinic, plus one that was a distance of 1057 miles. Fifteen subjects installed the system at home themselves after instruction in the clinic, while nine required a home visit to install. Three required follow-up visits to fix equipment. A post-treatment telephone survey was conducted to assess ease of use and most responded that the system was easy to use. Functional improvements were seen in the subjects enrolled in the formal treatment study, although the treatment period was too short to trigger cortical reorganization. We conclude that the system is feasible for home use and that tracking training has promise as a treatment paradigm.

1.
Lloyd-Jones
,
D.
,
Adams
,
R.
,
Carnethon
,
M.
,
De Simone
,
G.
,
Ferguson
,
T. B.
,
Flegal
,
K.
,
Ford
,
E.
,
Furie
,
K.
,
Go
,
A.
,
Greenlund
,
K.
,
Haase
,
N.
,
Hailpern
,
S.
,
Ho
,
M.
,
Howard
,
V.
,
Kissela
,
B.
,
Kittner
,
S.
,
Lackland
,
D.
,
Lisabeth
,
L.
,
Marelli
,
A.
,
McDermott
,
M.
,
Meigs
,
J.
,
Mozaffarian
,
D.
,
Nichol
,
G.
,
O’Donnell
,
C.
,
Roger
,
V.
,
Rosamond
,
W.
,
Sacco
,
R.
,
Sorlie
,
P.
,
Stafford
,
R.
,
Steinberger
,
J.
,
Thom
,
T.
,
Wasserthiel-Smoller
,
S.
,
Wong
,
N.
,
Wylie-Rosett
,
J.
, and
Hong
,
Y.
, 2009, “
Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
,”
Circulation
0009-7322,
119
(
3
), pp.
e21
181
.
2.
Jorgensen
,
H. S.
,
Nakayama
,
H.
,
Raaschou
,
H. O.
, and
Olsen
,
T. S.
, 1999, “
Stroke. Neurologic and Functional Recovery the Copenhagen Stroke Study
,”
Phys. Med. Rehabil. Clin. N. Am.
,
10
(
4
), pp.
887
906
.
3.
Hummelsheim
,
H.
,
Maier-Loth
,
M.
, and
Eickhof
,
C.
, 1997, “
The Functional Value of Electrical Muscle Stimulation for the Rehabilitation of the Hand in Stroke Patients
,”
Scand. J. Rehabil. Med.
0036-5505,
29
, pp.
3
10
.
4.
Nudo
,
R. J.
and
Friel
,
K. M.
, 1999, “
Cortical Plasticity After Stroke: Implications for Rehabilitation
,”
Rev. Neurol. (Paris)
0035-3787,
155
(
9
), pp.
713
717
.
5.
Chu
,
W. J.
,
Mason
,
G. F.
,
Pan
,
J. W.
,
Hetherington
,
H. P.
,
Liu
,
H. G.
,
San Pedro
,
E. C.
, and
Mountz
,
J. M.
, 2002, “
Regional Cerebral Blood Flow and Magnetic Resonance Spectroscopic Imaging Findings in Diaschisis From Stroke
,”
Stroke
0039-2499,
33
(
5
), pp.
1243
1248
.
6.
Feeney
,
D. M.
and
Baron
,
J. C.
, 1986, “
Diaschisis
,”
Stroke
0039-2499,
17
(
5
), pp.
817
830
.
7.
Schmidt
,
R.
, 1988,
Motor Control and Learning: A Behavioral Emphasis
,
Human Kinetics
,
Champaign, IL
.
8.
Winstein
,
C. J.
,
Pohl
,
P. S.
, and
Lewthwaite
,
R.
, 1994, “
Effects of Physical Guidance and Knowledge of Results on Motor Learning: Support for the Guidance Hypothesis
,”
Res. Q. Exerc Sport
0270-1367,
65
, pp.
316
323
.
9.
Krakauer
,
J. W.
, 2006, “
Motor Learning: Its Relevance to Stroke Recovery and Neurorehabilitation
,”
Curr. Opin. Neurol.
1350-7540,
19
(
1
), pp.
84
90
.
10.
Prabhakaran
,
S.
,
Zarahn
,
E.
,
Riley
,
C.
,
Speizer
,
A.
,
Chong
,
J. Y.
,
Lazar
,
R. M.
,
Marshall
,
R. S.
, and
Krakauer
,
J. W.
, 2008, “
Inter-Individual Variability in the Capacity for Motor Recovery After Ischemic Stroke
,”
Neurorehabil. Neural Repair
,
22
(
1
), pp.
64
71
.
11.
Taub
,
E.
, 1980, “
Somatosensory Deafferentation Research With Monkeys: Implications for Rehabilitation Medicine
,”
Behavioral Psychology in Rehabilitation Medicine: Clinical Applications
,
L.
Ince
, ed.,
Williams and Wilkins
,
New York
, pp.
371
401
.
12.
Taub
,
E.
, 2000, “
Constraint-Induced Movement Therapy and Massed Practice
,”
Stroke
0039-2499,
31
(
4
), pp.
986
988
.
13.
Lum
,
P. S.
,
Uswatte
,
G.
,
Taub
,
E.
,
Hardin
,
P.
, and
Mark
,
V. W.
, 2006, “
A Telerehabilitation Approach to Delivery of Constraint-Induced Movement Therapy
,”
J. Rehabil. Res. Dev.
0748-7711,
43
(
3
), pp.
391
400
.
14.
Liepert
,
J.
,
Bauder
,
H.
,
Wolfgang
,
H. R.
,
Miltner
,
W. H.
,
Taub
,
E.
, and
Weiller
,
C.
, 2000, “
Treatment-Induced Cortical Reorganization After Stroke in Humans
,”
Stroke
0039-2499,
31
(
6
), pp.
1210
1216
.
15.
Page
,
S. J.
,
Sisto
,
S.
,
Levine
,
P.
, and
McGrath
,
R. E.
, 2004, “
Efficacy of Modified Constraint-Induced Movement Therapy in Chronic Stroke: A Single-Blinded Randomized Controlled Trial
,”
Arch. Phys. Med. Rehabil.
0003-9993,
85
(
1
), pp.
14
18
.
16.
Taub
,
E.
,
Miller
,
N. E.
,
Novack
,
T. A.
,
Cook
,
E. W.
, 3rd
,
Fleming
,
W. C.
,
Nepomuceno
,
C. S.
,
Connell
,
J. S.
, and
Crago
,
J. E.
, 1993, “
Technique to Improve Chronic Motor Deficit After Stroke
,”
Arch. Phys. Med. Rehabil.
0003-9993,
74
(
4
), pp.
347
354
.
17.
Taub
,
E.
,
Uswatte
,
G.
, and
Pidikiti
,
R.
, 1999, “
Constraint-Induced Movement Therapy: A New Family of Techniques With Broad Application to Physical Rehabilitation—A Clinical Review
,”
J. Rehabil. Res. Dev.
0748-7711,
36
(
3
), pp.
237
251
.
18.
Wolf
,
S. L.
,
Winstein
,
C. J.
,
Miller
,
J. P.
,
Taub
,
E.
,
Uswatte
,
G.
,
Morris
,
D.
,
Giuliani
,
C.
,
Light
,
K. E.
, and
Nichols-Larsen
,
D.
, 2006, “
Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke: The EXCITE Randomized Clinical Trial
,”
JAMA, J. Am. Med. Assoc.
0098-7484,
296
(
17
), pp.
2095
2104
.
19.
Sveistrup
,
H.
, 2004, “
Motor Rehabilitation Using Virtual Reality
,”
J. Neuroeng. Rehabil.
,
1
(
1
), p.
10
.
20.
Holden
,
M. K.
, 2005, “
Virtual Environments for Motor Rehabilitation: Review
,”
Cyberpsychol Behav
,
8
(
3
), pp.
187
211
.
21.
Timmermans
,
A. A.
,
Seelen
,
H. A.
,
Willmann
,
R. D.
, and
Kingma
,
H.
, 2009, “
Technology-Assisted Training of Arm-Hand Skills in Stroke: Concepts on Reacquisition of Motor Control and Therapist Guidelines for Rehabilitation Technology Design
,”
J. Neuroeng. Rehabil.
,
6
, p.
1
.
22.
Riener
,
R.
,
Nef
,
T.
, and
Colombo
,
G.
, 2005, “
Robot-Aided Neurorehabilitation of the Upper Extremities
,”
Med. Biol. Eng. Comput.
0140-0118,
43
(
1
), pp.
2
10
.
23.
Huang
,
V. S.
and
Krakauer
,
J. W.
, 2009, “
Robotic Neurorehabilitation: A Computational Motor Learning Perspective
,”
J. Neuroeng. Rehabil.
,
6
, p.
5
.
24.
Fasoli
,
S. E.
,
Krebs
,
H. I.
,
Stein
,
J.
,
Frontera
,
W. R.
, and
Hogan
,
N.
, 2003, “
Effects of Robotic Therapy on Motor Impairment and Recovery in Chronic Stroke
,”
Arch. Phys. Med. Rehabil.
0003-9993,
84
(
4
), pp.
477
482
.
25.
Fasoli
,
S. E.
,
Krebs
,
H. I.
,
Stein
,
J.
,
Frontera
,
W. R.
,
Hughes
,
R.
, and
Hogan
,
N.
, 2004, “
Robotic Therapy for Chronic Motor Impairments After Stroke: Follow-Up Results
,”
Arch. Phys. Med. Rehabil.
0003-9993,
85
(
7
), pp.
1106
1111
.
26.
Krebs
,
H. I.
,
Hogan
,
N.
,
Aisen
,
M. L.
, and
Volpe
,
B. T.
, 1998, “
Robot-Aided Neurorehabilitation
,”
IEEE Trans. Rehabil. Eng.
1063-6528,
6
(
1
), pp.
75
87
.
27.
Kwakkel
,
G.
,
Kollen
,
B. J.
, and
Krebs
,
H. I.
, 2008, “
Effects of Robot-Assisted Therapy on Upper Limb Recovery After Stroke: A Systematic Review
,”
Neurorehabil. Neural Repair
,
22
(
2
), pp.
111
121
.
28.
Macclellan
,
L. R.
,
Bradham
,
D. D.
,
Whitall
,
J.
,
Volpe
,
B.
,
Wilson
,
P. D.
,
Ohlhoff
,
J.
,
Meister
,
C.
,
Hogan
,
N.
,
Krebs
,
H. I.
, and
Bever
,
C. T.
, Jr.
, 2005, “
Robotic Upper-Limb Neurorehabilitation in Chronic Stroke Patients
,”
J. Rehabil. Res. Dev.
0748-7711,
42
(
6
), pp.
717
722
.
29.
Koeneman
,
E. J.
,
Schultz
,
R. S.
,
Wolf
,
S. L.
,
Herring
,
D. E.
, and
Koeneman
,
J. B.
, 2004, “
A Pneumatic Muscle Hand Therapy Device
,”
26th Annual International Conference of the IEEE EMBS
.
30.
Colombo
,
G.
,
Joerg
,
M.
,
Schreier
,
R.
, and
Dietz
,
V.
, 2000, “
Treadmill Training of Paraplegic Patients Using a Robotic Orthosis
,”
J. Rehabil. Res. Dev.
0748-7711,
37
(
6
), pp.
693
700
.
31.
Hesse
,
S.
, 2008, “
Treadmill Training With Partial Body Weight Support After Stroke: A Review
,”
NeuroRehabilitation
,
23
(
1
), pp.
55
65
.
32.
Hidler
,
J.
,
Nichols
,
D.
,
Pelliccio
,
M.
,
Brady
,
K.
,
Campbell
,
D. D.
,
Kahn
,
J. H.
, and
Hornby
,
T. G.
, 2009, “
Multicenter Randomized Clinical Trial Evaluating the Effectiveness of the Lokomat in Subacute Stroke
,”
Neurorehabil. Neural Repair
,
23
(
1
), pp.
5
13
.
33.
Anderson
,
C.
,
Rubenach
,
S.
,
Mhurchu
,
C. N.
,
Clark
,
M.
,
Spencer
,
C.
, and
Winsor
,
A.
, 2000, “
Home or Hospital for Stroke Rehabilitation? Results of a Randomized Controlled Trial: I: Health Outcomes at 6 Months
,”
Stroke
0039-2499,
31
(
5
), pp.
1024
1031
.
34.
Beech
,
R.
,
Rudd
,
A. G.
,
Tilling
,
K.
, and
Wolfe
,
C. D.
, 1999, “
Economic Consequences of Early Inpatient Discharge to Community-Based Rehabilitation for Stroke in an Inner-London Teaching Hospital
,”
Stroke
0039-2499,
30
(
4
), pp.
729
735
.
35.
Widen Holmqvist
,
L.
,
von Koch
,
L.
,
Kostulas
,
V.
,
Holm
,
M.
,
Widsell
,
G.
,
Tegler
,
H.
,
Johansson
,
K.
,
Almazan
,
J.
, and
de Pedro-Cuesta
,
J.
, 1998, “
A Randomized Controlled Trial of Rehabilitation at Home After Stroke in Southwest Stockholm
,”
Stroke
0039-2499,
29
(
3
), pp.
591
597
.
36.
Young
,
J. B.
and
Forster
,
A.
, 1992, “
The Bradford Community Stroke Trial: Results at Six Months
,”
BMJ
0959-8138,
304
(
6834
), pp.
1085
1089
.
37.
Carey
,
J. R.
,
Kimberley
,
T. J.
,
Lewis
,
S. M.
,
Auerbach
,
E. J.
,
Dorsey
,
L.
,
Rundquist
,
P.
, and
Ugurbil
,
K.
, 2002, “
Analysis of fMRI and Finger Tracking Training in Subjects With Chronic Stroke
,”
Brain
0006-8950,
125
(
Pt 4
), pp.
773
788
.
38.
Kraft
,
G. H.
,
Fitts
,
S. S.
, and
Hammond
,
M. C.
, 1992, “
Techniques to Improve Function of the Arm and Hand in Chronic Hemiplegia
,”
Arch. Phys. Med. Rehabil.
0003-9993,
73
, pp.
220
227
.
39.
Kunkel
,
A.
,
Kopp
,
B.
,
Muller
,
G.
,
Villringer
,
K.
,
Villringer
,
A.
,
Taub
,
E.
, and
Flor
,
H.
, 1999, “
Constraint-Induced Movement Therapy for Motor Recovery in Chronic Stroke Patients
,”
Arch. Phys. Med. Rehabil.
0003-9993,
80
, pp.
624
628
.
40.
Luft
,
A. R.
,
McCombe-Waller
,
S.
,
Whitall
,
J.
,
Forrester
,
L. W.
,
Macko
,
R.
,
Sorkin
,
J. D.
,
Schulz
,
J. B.
,
Goldberg
,
A. P.
, and
Hanley
,
D. F.
, 2004, “
Repetitive Bilateral Arm Training and Motor Cortex Activation in Chronic Stroke: A Randomized Controlled Trial
,”
JAMA, J. Am. Med. Assoc.
0098-7484,
292
(
15
), pp.
1853
1861
.
41.
Theodoros
,
D.
and
Russell
,
T.
, 2008, “
Telerehabilitation: Current Perspectives
,”
Stud. Health Technol. Inform.
0926-9630,
131
, pp.
191
209
.
42.
Russell
,
T. G.
, 2007, “
Physical Rehabilitation Using Telemedicine
,”
J. Telemed Telecare
1357-633X,
13
(
5
), pp.
217
220
.
43.
Kairy
,
D.
,
Lehoux
,
P.
,
Vincent
,
C.
, and
Visintin
,
M.
, 2009, “
A Systematic Review of Clinical Outcomes, Clinical Process, Healthcare Utilization and Costs Associated With Telerehabilitation
,”
Disabil Rehabil.
0963-8288,
31
(
6
), pp.
427
447
.
44.
Dhurjaty
,
S.
, 2004, “
The Economics of Telerehabilitation
,”
Telemed. J. E Health
,
10
(
2
), pp.
196
199
.
45.
Reinkensmeyer
,
D. J.
,
Pang
,
C. T.
,
Nessler
,
J. A.
, and
Painter
,
C. C.
, 2002, “
Web-Based Telerehabilitation for the Upper Extremity After Stroke
,”
IEEE Trans. Neural Syst. Rehabil. Eng.
1534-4320,
10
(
2
), pp.
102
108
.
46.
Feng
,
X.
and
Winters
,
J.
, 2005, “
UniTherapy: A Computer-Assisted Motivating Neurorehabilitation Platform for Teleassessment and Remote Therapy
,”
IEEE Ninth International Conference of Rehabilitation Robotics
, pp.
349
352
.
47.
Carey
,
J. R.
,
Bhatt
,
E.
, and
Nagpal
,
A.
, 2005, “
Neuroplasticity Promoted by Task Complexity
,”
Exerc Sport Sci. Rev.
0091-6331,
33
(
1
), pp.
24
31
.
48.
Schmidt
,
R.
, 1991, “
Frequent Augmented Feedback Can Degrade Learning: Evidence and Interpretations
,”
Tutorials in Motor Neuroscience
,
J.
Requin
and
G.
Stelmach
, eds.,
Kluwer Academic
,
Dordrecht, The Netherlands
, pp.
59
75
.
49.
Carey
,
J. R.
,
Anderson
,
K. M.
,
Kimberley
,
T. J.
,
Lewis
,
S. M.
,
Auerbach
,
E. J.
, and
Ugurbil
,
K.
, 2004, “
fMRI Analysis of Ankle Movement Tracking Training in Subject With Stroke
,”
Exp. Brain Res.
0014-4819,
154
(
3
), pp.
281
290
.
50.
Tilley
,
A. R.
, 2001,
The Measure of Man and Woman: Human Factors in Design
,
Wiley
,
New York
.
51.
Carey
,
J. R.
, 1990, “
Effect on Finger Movement Control and Force Control in Stroke Subjects With Spastic Extrinsic Finger Flexor Muscles
,”
Arch Phys. Med. Rehabil.
,
71
, pp.
888
894
.
52.
Schmidt
,
R. A.
, and
Lee
,
T. D.
, 2005, “
Motor Control and Learning–A Behavioral Emphasis
,” 4th ed., Human Kinetics, Champaign, IL.
53.
Greenough
,
W. T.
,
Larson
,
J. R.
, and
Withers
,
G. S.
, 1985, “
Effects of Unilateral and Bilateral Training in a Reaching Task on Dendritic Branching of Neurons in the Rat Motor-Sensory Forelimb Cortex
,”
Behav. Neural Biol.
0163-1047,
44
(
2
), pp.
301
314
.
54.
Imamizu
,
H.
,
Uno
,
Y.
, and
Kawato
,
M.
, 1998, “
Adaptive Internal Model of Intrinsic Kinematics Involved in Learning an Aiming Task
,”
J. Exp. Psychol. Hum. Percept. Perform.
0096-1523,
24
(
3
), pp.
812
829
.
55.
Shields
,
R. K.
,
Leo
,
K. C.
,
Messaros
,
A. J.
, and
Somers
,
V. K.
, 1999, “
Effects of Repetitive Handgrip Training on Endurance, Specificity, and Cross-Education
,”
Phys. Ther.
0031-9023,
79
(
5
), pp.
467
475
.
56.
Carey
,
J. R.
,
Baxter
,
T. L.
, and
Di Fabio
,
R. P.
, 1998, “
Tracking Control in the Nonparetic Hand of Subjects With Stroke
,”
Arch. Phys. Med. Rehabil.
0003-9993,
79
(
4
), pp.
435
441
.
57.
Dail
,
T. K.
and
Christina
,
R. W.
, 2004, “
Distribution of Practice and Metacognition in Learning and Long-Term Retention of a Discrete Motor Task
,”
Res. Q. Exerc Sport
0270-1367,
75
(
2
), pp.
148
155
.
58.
Lee
,
T. D.
and
Genovese
,
E. D.
, 1989, “
Distribution of Practice in Motor Skill Acquisition: Different Effects for Discrete and Continuous Tasks
,”
Res. Q. Exerc Sport
0270-1367,
60
(
1
), pp.
59
65
.
59.
Carey
,
J. R.
,
Durfee
,
W. K.
,
Bhatt
,
E.
,
Nagpal
,
A.
,
Weinstein
,
S. A.
,
Anderson
,
K. M.
, and
Lewis
,
S. M.
, 2007, “
Comparison of Finger Tracking Versus Simple Movement Training Via Telerehabilitation to Alter Hand Function and Cortical Reorganization After Stroke
,”
Neurorehabil. Neural Repair
,
21
(
3
), pp.
216
232
.
60.
Folstein
,
M. F.
,
Folstein
,
S. E.
, and
McHugh
,
P. R.
, 1975, “
“Mini-Mental State:” A Practical Method for Grading the Cognitive State of Patients for the Clinician
,”
J. Psychiatr. Res.
0022-3956,
12
(
3
), pp.
189
198
.
61.
Mathiowetz
,
V.
,
Volland
,
G.
,
Kashman
,
N.
, and
Weber
,
K.
, 1985, “
Adult Norms for the Box and Block Test of Manual Dexterity
,”
Am. J. Occup. Ther.
0272-9490,
39
(
6
), pp.
386
391
.
62.
Jebsen
,
R. H.
,
Taylor
,
N.
,
Trieschmann
,
R. B.
,
Trotter
,
M. J.
, and
Howard
,
L. A.
, 1969, “
An Objective and Standardized Test of Hand Function
,”
Arch. Phys. Med. Rehabil.
0003-9993,
50
(
6
), pp.
311
319
.
You do not currently have access to this content.